{"product_id":"sam-e-200-mg-enteric-coated","title":"SAM-e 200 mg Enteric Coated","description":"\u003ch2\u003eSAM-e 200 mg Enteric Coated\u003c\/h2\u003e\n\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eSAM-e tablets deliver 200 mg of S-adenosyl-methionine in an enteric-coated form for added stability\u003c\/p\u003e\n\u003ch3\u003eFunctions\u003c\/h3\u003e\n\u003cp\u003eSAM-e (S-adenosyl-methionine) has been shown to be efficacious in several health disorders. Although SAMe, as a methyl donor, participates in a wide variety of biochemical reactions, it can provide important support for the healthy functioning of joints, neurological processes and the liver. SAM-e's joint support lies not only in its ability to help regulate the body's normal inflammatory processes, but also on its putative participation in proteoglycan synthesis and joint cartilage repair. SAM-e is thought to function physiologically as a signal of sulfur availability. Some suggest that supplemental SAM-e may compensate for the decreased SAM-e levels in chondrocytes induced by the inflammatory cytokine interleukin-1, and thus upregulate the chondrocyte's synthesis of joint proteoglycans. As a major source of methyl groups in the brain, SAM-e, in conjunction with other methyl donor metabolites such as betaine, choline, or folate, may optimize the synthetic\/ degradative rate of neurotransmitters, i.e. serotonin and dopamine, and the brain's sensitivity to them. With few side effects SAM-e has been shown in meta analysis of multiple studies to offer tangible support for healthy mental functioning. As a hepatoprotective compound, SAM-e has been shown to be useful to support the body's response to adverse biochemical alterations induced by lead and\/or alcohol exposure. This characteristic of SAM-e's activity is also effective in protecting the central nervous system. SAM-e can be an integral part of a hepatoprotective therapeutic regimen. Other studies have indicated that SAM-e may decrease cholestasis. By optimizing a healthy flow of bile, SAM-e can support a healthy gastrointestinal tract\u003c\/p\u003e\n\u003ch3\u003eIndications\u003c\/h3\u003e\n\u003cp\u003eSAM-e tablets may be a useful nutritional supplement for individuals looking for its neurological as well as joint-related benefits\u003c\/p\u003e\n\u003ch3\u003eSupplement Facts\u003c\/h3\u003e\n\u003cdiv class=\"supplement-facts\"\u003e\n\u003cp class=\"serving-size\"\u003e\u003cstrong\u003e1 Tablet Contains\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable class=\"supplement-facts-table\" style=\"width:100%; max-width:480px; border-collapse:collapse; margin:12px 0;\"\u003e\u003ctbody\u003e\u003ctr style=\"border-bottom:1px solid #e5e5e5;\"\u003e\n\u003ctd style=\"padding:6px 8px 6px 0;\"\u003eSAM-e (from 400 mg of s-adenosyl-l-methionine disulfate tosylate)\u003c\/td\u003e\n\u003ctd style=\"text-align:right; white-space:nowrap; padding:6px 0 6px 16px;\"\u003e\u003cstrong\u003e200 mg\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\u003c\/tbody\u003e\u003c\/table\u003e\n\u003cp class=\"other-ingredients\"\u003e\u003cstrong\u003eOther Ingredients:\u003c\/strong\u003e Cellulose, silica, magnesium stearate, ethyl cellulose, oleic acid, medium chain triglycerides, sodium alginate, modified cellulose, triacetin, calcium carbonate, and riboflavin (for color).\u003c\/p\u003e\n\u003cp class=\"allergen-info\"\u003e\u003cem\u003eThis product contains NO sugar, salt, dairy, yeast, wheat, gluten, corn, soy, preservatives, artificial colors or flavors.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch3\u003eSuggested Use\u003c\/h3\u003e\n\u003cp\u003eAs a dietary supplement, adults take 1 tablet, 2 times daily between meals, or as directed by a healthcare professional\u003c\/p\u003e\n\u003ch3\u003eSide Effects\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eNo adverse effects have been reported\u003c\/strong\u003e\u003c\/p\u003e\n\u003ch3\u003eStorage\u003c\/h3\u003e\n\u003cp\u003eStore in a cool, dry place, away from direct light. Keep out of reach of children\u003c\/p\u003e\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003col class=\"references\" start=\"1\" style=\"margin:12px 0; padding-left:24px; list-style-type:decimal;\"\u003e\n\u003cli value=\"1\"\u003eBottiglieri, T, Hyland, K, Reynolds, EH. The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders. Drugs 1994;48:137-52\u003c\/li\u003e\n\u003cli value=\"2\"\u003eBressa, GM. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl 1994;154:7-14\u003c\/li\u003e\n\u003cli value=\"3\"\u003eDomljan, Z, Vrhovac, B, Durrigl, T, Pucar, I. A double-blind trial of ademetionine vs naproxen in activated gonarthrosis. Int J Clin Pharmacol Ther Toxicol 1989;27:329-33\u003c\/li\u003e\n\u003cli value=\"4\"\u003eFlora, GJ, Seth, PK. Beneficial effects of S-adenosyl-L-methionine on aminolevulinic acid dehydratase, glutathione, and lipid peroxidation during acute lead- ethanol administration in mice. Alcohol 1999;18:103-8\u003c\/li\u003e\n\u003cli value=\"5\"\u003eGoodnick, PJ, Sandoval, R. Psychotropic treatment of chronic fatigue syndrome and related disorders. J Clin Psychiatry 1993;54:13-20. Ter Arkh 1998;70:82-6\u003c\/li\u003e\n\u003cli value=\"6\"\u003eMato, JM, Camara, J, Fernandez de Paz, J, Caballeria, L, Coll, S, Caballero, A, Garcia- Buey, L, Beltran, J, Benita, V , Caballeria, J, Sola, R, Moreno-Otero, R, Barrao, F, Martin-Duce, A, Correa, JA, Pares, A, Barrao, E, Garcia-Magaz, I, Puerta, JL, Moreno, J, Boissard, G, Ortiz, P, Rodes, J. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol 1999;30:1081-9\u003c\/li\u003e\n\u003cli value=\"7\"\u003eMcCarty, MF, Russell, AL. Niacinamide therapy for osteoarthritis--does it inhibit nitric oxide synthase induction by interleukin 1 in chondrocytes? Med Hypotheses 1999;53:350-60\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003eThese statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e","brand":"My Concierge Pharmacy","offers":[{"title":"Default Title","offer_id":51818528211234,"sku":"10130","price":65.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0928\/9429\/8402\/files\/FrontLabel_02875aec-d496-4509-933d-244b1ca2101c.png?v=1783471525","url":"https:\/\/shop.myconciergepharmacy.com\/products\/sam-e-200-mg-enteric-coated","provider":"My Concierge Pharmacy","version":"1.0","type":"link"}