Metabolic Probiotic with Akkermansia

Metabolic Probiotic with Akkermansia

Description

Glucagon-like-peptide-1, or GLP-1, is a naturally occurring hormone produced in the gut. This hormone assists with metabolism, insulin balance, gastric emptying and satiety to help promote healthy blood sugar levels, curb cravings and maintain a healthy weight. Akkermansia muciniphila is a probiotic strain that secretes a protein that induces natural production of GLP-1 in the gut.1 Metabolic Probiotic with Akkermansia contains 100 million CFU of this beneficial bacteria strain combined with 4 other strains to support immune, gut and metabolic health and help maintain a healthy weight

Functions

Metabolic Probiotic with Akkermansia is a specially formulated probiotic supplement designed to support overall gut health, immune function and metabolic balance.1 This supplement features a potent blend of scientifically backed bacterial strains that target the gut microbiome to support a healthy balance of beneficial bacteria. Each ingredient has been carefully selected for its unique properties and mechanisms of action, contributing to the supplement's comprehensive benefits. The Bifidobacterium animalis HN019 strain enhances gut health by influencing colonic motility to increase gut transit and improve bowel regularity and metabolic processes. Additionally, this strain helps to improve the gut barrier which is crucial for healthy immune and inflammatory responses.2-5 The Bifidobacterium animalis B420 strain aids in weight management and supports metabolic health by influencing gut microbiota composition and promoting the production of short-chain fatty acids (SCFAs) that support energy metabolism.6,7 It also helps with healthy body composition by supporting intestinal barrier function and promoting healthy inflammatory markers.8,9 Lactobacillus rhamnosus GG is believed to support gastrointestinal health and immune balance. It may help to promote the structural and functional integrity of the gut barrier.10-14 It also supports the composition and activity of the gut microbiome, promoting an increase in beneficial bacteria and the production of SCFAs.12-14 These actions may help to maintain a healthy intestinal environment, promote healthy inflammatory markers, and support metabolic functions. Akkermansia muciniphila AH39 is a unique strain targeting the mucosal layer of the gut, which is critical for supporting healthy gut barrier integrity and promoting healthy inflammatory markers.15,16 This strain's role in modulating the gut microbiota also contributes to supporting healthy metabolic outcomes and weight management by promoting natural production of GLP-1.1,17-18 This strain further promotes healthy systemic metabolic outcomes through its modulation of the endocannabinoid system (ECS) within the gut lining, which is instrumental in supporting energy balance and glucose homeostasis.1,17-18 This interaction highlights AH39's potential in managing weight and supporting healthy glucose metabolism. The strain's dual action of promoting a healthy gut barrier and supporting the ECS underscores its significance in contributing to metabolic health and maintaining a balanced immune response.17-18 Clostridium butyricum nourishes the gut lining, promotes healthy inflammatory markers and supports healthy barrier function.19 Clostridium butyricum 10 is known for its butyrate- producing capabilities. Butyrate is a primary energy source for colonocytes, supporting their health and promoting a robust intestinal barrier. It also supports the healthy expression of tight junction proteins, further enhancing barrier integrity

Indications

Metabolic Probiotic with Akkermanisa may be a beneficial adjunct therapy for patients looking to maintain a healthy weight. This product may be helpful for those avoiding GLP-1 agonist prescription medications, those taking GLP-1 medications as well as those looking to titrate down or off of GLP-1 medications. Continued on following page Metabolic Probiotic With Akkermansia

Supplement Facts

Suggested Use

As a dietary supplement, adults take 1 capsule daily, or as directed by a healthcare professional

Storage

Store in a cool, dry place, away from direct light and out of reach of children

References

1. Yoon, H. S., Cho, C. H., Yun, M. S., Jang, S. J., You, H. J., Kim, J., Han, D., Cha, K. H., Moon, S. H., Lee, K., Kim, Y .-J., Lee, S.-J., Nam, T.-W., & Ko, G. (2021). Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ame- liorates metabolic disease in mice. Nature Microbiology, 6(5), 563–573. https://doi.org/10.1038/s41564-021-00880-5 2
2. DiMattia, Z., Damani, J. J., Van Syoc, E., & Rogers, C. J. (2024). Effect of probiotic supplementation on intestinal permeability in overweight and obesity: A systematic review of randomized controlled trials and Animal Studies. Advances in Nutrition, 15(1), 100162. https://doi.org/10.1016/j.advnut.2023.100162 3
3. TAKAHASHI, S., ANZAWA, D., TAKAMI, K., ISHIZUKA, A., MAWATARI, T., KAMIKADO, K., SUGIMURA, H., & NISHIJIMA, T. (2016). Effect of bifidobacterium animalis ssp lactis GCL2505 on visceral fat accumulation in healthy Japanese adults: A randomized controlled trial. Bioscience of Microbiota, Food and Health, 35(4), 163–171. https://doi.org/10.12938/bmfh.2016-002 4
4. Chen, A.-C., Fang, T.-J., Ho, H.-H., Chen, J.-F., Kuo, Y .-W., Huang, Y .- Y ., Tsai, S.-Y ., Wu, S.-F., Lin, H.-C., & Yeh, Y .-T. (2022). A multi-strain probiotic blend reshaped obesity-related gut dysbiosis and improved lipid metabolism in obese children. Frontiers in Nutrition, 9. https://doi.org/10.3389/fnut.2022.922993 5
5. Gopal, P. K., Prasad, J., & Gill, H. S. (2003). Effects of the consumption of Bifidobacterium Lactis HN019 (DR10TM) and Galacto-oligosaccha- rides on the microflora of the gastrointestinal tract in human subjects. Nutrition Research, 23(10), 1313–1328. https://doi.org/10.1016/s0271- 5317(03)00134-9 6
6. Stenman, L. K., Waget, A., Garret, C., Briand, F., Burcelin, R., Sulpice, T., & Lahtinen, S. (2015). Probiotic B420 and prebiotic polydextrose improve efficacy of antidiabetic drugs in mice. Diabetology & Metabolic Syndrome, 7(1). https://doi.org/10.1186/s13098-015-0075-7 7
7. Stenman, L. K., Lehtinen, M. J., Meland, N., Christensen, J. E., Yeung, N., Saarinen, M. T., Courtney, M., Burcelin, R., Lähdeaho, M.-L., Lin- ros, J., Apter, D., Scheinin, M., Kloster Smerud, H., Rissanen, A., & Lahtinen, S. (2016). Probiotic with or without fiber controls body fat mass, associated with serum zonulin, in overweight and obese adults— randomized controlled trial. EBioMedicine, 13, 190–200. https://doi.org/10.1016/j.ebiom.2016.10.036 8
8. Uusitupa, H.-M., Rasinkangas, P., Lehtinen, M. J., Mäkelä, S. M., Airak- sinen, K., Anglenius, H., Ouwehand, A C., & Maukonen, J. (2020). Bifi- dobacterium animalis subsp lactis 420 for Metabolic Health: Review of the research. Nutrients, 12(4), 892. https://doi.org/10.3390/nu12040892 9
9. Wastyk, H. C., Perelman, D., Topf, M., Fragiadakis, G. K., Robinson, J. L., Sonnenburg, J. L., Gardner, C. D., & Sonnenburg, E. D. (2023). Ran- domized controlled trial demonstrates response to a probiotic interven- tion for metabolic syndrome that may correspond to Diet. Gut Microbes, 15(1). https://doi.org/10.1080/19490976.2023.2178794 10
10. Fong, F., Kirjavainen, P. & El-Nezami, H. Immunomodulation of Lac- tobacillus rhamnosus GG (LGG)-derived soluble factors on antigen- presenting cells of healthy blood donors. Sci Rep 6, 22845 (2016). https://doi.org/10.1038/srep22845. 11
11. Ludwig, I. S., Broere, F., Manurung, S., Lambers, T. T., van der Zee, R., & van Eden, W. (2018). Lactobacillus rhamnosus GG-derived soluble mediators modulate adaptive immune cells. Frontiers in Immunology, 9. https://doi.org/10.3389/fimmu.2018.01546 12
12. Salemi, R., Vivarelli, S., Ricci, D et al. Lactobacillus rhamnosus GG cell-free supernatant as a novel anti-cancer adjuvant. J Transl Med 21, 195 (2023). https://doi.org/10.1186/s12967-023-04036-313. 13
13. Owens, J. A., Saeedi, B. J., Naudin, C. R., Hunter-Chang, S., Barbian, M. E., Eboka, R. U., Askew, L., Darby, T. M., Robinson, B. S., & Jones, R. M. (2021). Lactobacillus rhamnosus GG orchestrates an antitumor immune response. Cellular and Molecular Gastroenterology and Hepa- tology, 12(4), 1311–1327. https://doi.org/10.1016/j.jcmgh.2021.06.001 14
14. Banna, G. L., Torino, F., Marletta, F., Santagati, M., Salemi, R., Cann- arozzo, E., Falzone, L., Ferraù, F., & Libra, M. (2017). Lactobacillus rhamnosus GG: An overview to explore the rationale of its use in cancer. Frontiers in Pharmacology, 8. https://doi.org/10.3389/fphar.2017.00603 15
15. Alim, A., Li, T., Nisar, T., Ali, Z., Ren, D., Liu, Y ., & Yang, X. (2023). Polyphenols and pectin enriched golden kiwifruit (Actinidia chinensis) alleviates high fructose-induced glucolipid disorders and hepatic oxida- tive damage in rats: In association with improvement of fatty acids me- tabolism. Food Science and Human Wellness, 12(5), 1872–1884 https:// doi.org/10.1016/j.fshw.2023.02.039 16
16. Rodrigues, V. F., Elias-Oliveira, J., Pereira, Í. S., Pereira, J. A., Barbosa, S. C., Machado, M. S., & Carlos, D. (2022). Akkermansia muciniphila and gut immune system: A good friendship that attenuates inflamma- tory bowel disease, obesity, and diabetes. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.934695 17
17. Zhou, Q., Pang, G., Zhang, Z., Yuan, H., Chen, C., Zhang, N., Yang, Z., & Sun, L. (2021). Association between Gut Akkermansia and metabolic syndrome is dose-dependent and affected by microbial interactions: A cross-sectional study
18. Abuqwider, J. N., Mauriello, G., & Altamimi, M. (2021). Akkermansia muciniphila, a new generation of beneficial microbiota in modulating obesity: A systematic review. Microorganisms, 9(5), 1098. https://doi.org/10.3390/microorganisms9051098 19
19. Wang, Y ., Gu, Y ., Fang, K., Mao, K., Dou, J., Fan, H., Zhou, C., & Wang, H. (2018). Lactobacillus acidophilus and clostridium butyricum ameliorate colitis in murine by strengthening the gut barrier function and decreasing inflammatory factors. Beneficial Microbes, 9(5), 775–788. https://doi.org/10.3920/bm2017.0035

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.