SAM-e 200 mg Enteric Coated

SAM-e 200 mg Enteric Coated

Description

SAM-e tablets deliver 200 mg of S-adenosyl-methionine in an enteric-coated form for added stability

Functions

SAM-e (S-adenosyl-methionine) has been shown to be efficacious in several health disorders. Although SAMe, as a methyl donor, participates in a wide variety of biochemical reactions, it can provide important support for the healthy functioning of joints, neurological processes and the liver. SAM-e's joint support lies not only in its ability to help regulate the body's normal inflammatory processes, but also on its putative participation in proteoglycan synthesis and joint cartilage repair. SAM-e is thought to function physiologically as a signal of sulfur availability. Some suggest that supplemental SAM-e may compensate for the decreased SAM-e levels in chondrocytes induced by the inflammatory cytokine interleukin-1, and thus upregulate the chondrocyte's synthesis of joint proteoglycans. As a major source of methyl groups in the brain, SAM-e, in conjunction with other methyl donor metabolites such as betaine, choline, or folate, may optimize the synthetic/ degradative rate of neurotransmitters, i.e. serotonin and dopamine, and the brain's sensitivity to them. With few side effects SAM-e has been shown in meta analysis of multiple studies to offer tangible support for healthy mental functioning. As a hepatoprotective compound, SAM-e has been shown to be useful to support the body's response to adverse biochemical alterations induced by lead and/or alcohol exposure. This characteristic of SAM-e's activity is also effective in protecting the central nervous system. SAM-e can be an integral part of a hepatoprotective therapeutic regimen. Other studies have indicated that SAM-e may decrease cholestasis. By optimizing a healthy flow of bile, SAM-e can support a healthy gastrointestinal tract

Indications

SAM-e tablets may be a useful nutritional supplement for individuals looking for its neurological as well as joint-related benefits

Supplement Facts

Suggested Use

As a dietary supplement, adults take 1 tablet, 2 times daily between meals, or as directed by a healthcare professional

Side Effects

No adverse effects have been reported

Storage

Store in a cool, dry place, away from direct light. Keep out of reach of children

References

1. Bottiglieri, T, Hyland, K, Reynolds, EH. The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders. Drugs 1994;48:137-52
2. Bressa, GM. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl 1994;154:7-14
3. Domljan, Z, Vrhovac, B, Durrigl, T, Pucar, I. A double-blind trial of ademetionine vs naproxen in activated gonarthrosis. Int J Clin Pharmacol Ther Toxicol 1989;27:329-33
4. Flora, GJ, Seth, PK. Beneficial effects of S-adenosyl-L-methionine on aminolevulinic acid dehydratase, glutathione, and lipid peroxidation during acute lead- ethanol administration in mice. Alcohol 1999;18:103-8
5. Goodnick, PJ, Sandoval, R. Psychotropic treatment of chronic fatigue syndrome and related disorders. J Clin Psychiatry 1993;54:13-20. Ter Arkh 1998;70:82-6
6. Mato, JM, Camara, J, Fernandez de Paz, J, Caballeria, L, Coll, S, Caballero, A, Garcia- Buey, L, Beltran, J, Benita, V , Caballeria, J, Sola, R, Moreno-Otero, R, Barrao, F, Martin-Duce, A, Correa, JA, Pares, A, Barrao, E, Garcia-Magaz, I, Puerta, JL, Moreno, J, Boissard, G, Ortiz, P, Rodes, J. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol 1999;30:1081-9
7. McCarty, MF, Russell, AL. Niacinamide therapy for osteoarthritis--does it inhibit nitric oxide synthase induction by interleukin 1 in chondrocytes? Med Hypotheses 1999;53:350-60

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.